Phenotype Image Detail

Image

Caption

Raf1^tm1.1Bgn/Raf1⁺ (L613V/+) mice show multiple Noonan syndrome phenotypes. (A) Short stature in the mutant mice. Gross appearance of 2-month-old wild-type (WT) and mutant male mice and growth curves of WT (n = 45) and mutant (n = 45) male mice are shown. Differences were significant at all time points (P < 0.0001, 2-way repeated-measures ANOVA; ***P < 0.0001, Bonferroni post-test). (B) Mutant mice have facial dysmorphia. Gross facial appearance and representative microCT scans of skulls from WT and mutant mice. Double-headed arrows indicate inner canthal distance. (D) Splenomegaly in mutant mice. Representative gross appearance and spleen weight/BW ratio in WT (n = 25) and mutant (n = 25) mice at 4 months. ***P < 0.0001, 2-tailed Student's t test.

Copyright

This image is from Wu X, J Clin Invest 2011 Mar 1;121(3):1009-25 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:172034

Associated Alleles

Symbol	Name
Raf1^tm1.1Bgn	v-raf-leukemia viral oncogene 1; targeted mutation 1.1, Benjamin G Neel

Associated Genotypes

Allelic Composition	Genetic Background
Raf1^tm1.1Bgn/Raf1^+	involves: 129S6/SvEvTac * C57BL/6NCr