Phenotype Image Detail

Image

Caption

Cops6 is enssential for gamma-irradiation-induced apoptosis in the mouse thymus and developing CNS. (B) TUNEL analysis of thymus sections in Cops6^{Gt(RRI087)Byg}/Cops6⁺ and wild-type mice after gamma-irradiation. Apoptosis was analyzed by TUNEL assay in the thymus sections (original magnification, 400). Number of TUNEL+ cells per field was measured. P values were determined by 2-tailed t test. (D) Central nervous system (CNS) of embryos assayed for apoptosis by cleaved caspase-3 staining. Sagittal sections of embryos were stained for cleaved caspase-3 (original magnification, 100). Ventricular zone (VZ), intermediate zone (IZ), and marginal zone (MZ) of the CNS are indicated. Number of cleaved caspase-3+ cells per field was measured. P values were determined by 2-tailed t test.

Copyright

This image is from Zhao R, J Clin Invest 2011 Mar 1;121(3):851-65 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:172038

Associated Alleles

Symbol	Name
Cops6^Gt(RRI087)Byg	COP9 signalosome subunit 6; gene trap RRI087, BayGenomics

Associated Genotypes

Allelic Composition	Genetic Background
Cops6^Gt(RRI087)Byg/Cops6^+	involves: 129P2/OlaHsd * C57BL/6J