Phenotype Image Detail

Image

Caption

Representative images of spleen (C) and liver from Notch1^tm3(cre)Rko/Notch1⁺ (N1::Cre^lo/+) (D) and Notch1^tm3(cre)Rko/Notch1^tm2Rko (N1::Cre^lo/fl) animals (E and F). (E) Liver from a naturally deceased animal. (F) Liver from a euthanized mutant animal, in which the tumors were still intact and filled with blood. (G-I) H&E liver sections from controls (N1::Cre^lo/+) (G) and homozygous (N1::Cre^lo/fl) animals (H and I). (J-L) Immunostaining of liver tumor for PECAM (J), vWF (K), and PECAM and Ki67 (L). Inset in L shows the enlrged view of boxed area. Representative vascular tumors in other organs are shown in M (skin; H&E) and N (ovary; vWF). Scale bars: 50 um; 10 um (L, inset).

Copyright

This image is from Liu Z, J Clin Invest 2011 Feb 1;121(2):800-8 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:171829

Associated Alleles

Symbol	Name
Notch1^tm2Rko	notch 1; targeted mutation 2, Raphael Kopan
Notch1^tm3(cre)Rko	notch 1; targeted mutation 3, Raphael Kopan

Associated Genotypes

Allelic Composition	Genetic Background
Notch1^tm2Rko/Notch1^tm3(cre)Rko	involves: 129X1/SvJ * C57BL/6