About   Help   FAQ
Phenotype Image Detail
Image
Caption Electron micrograph images of aortas from 12- to 14-month-old animals expressing the R1031C mutation, Gt(ROSA)26Sortm3(NOTCH3*R1031C)Sat/Gt(ROSA)26Sor+ Tg(Tagln-cre)1Her/0 (CADASIL), (B) show thinner layers of vascular smooth muscle cells (vSMCs) compared with controls (A).
Copyright This image is from Arboleda-Velasquez JF, Proc Natl Acad Sci U S A 2011 May 24;108(21):E128-35. Copyright 2011 National Academy of Sciences, U.S.A. J:171887
Associated
Alleles
Symbol Name
Gt(ROSA)26Sortm3(NOTCH3*R1031C)Sat gene trap ROSA 26, Philippe Soriano; targeted mutation 3, Spyros Artavanis-Tsakonas
Tg(Tagln-cre)1Her transgene insertion 1, Joachim Herz
Associated
Genotypes
Allelic Composition Genetic Background
Gt(ROSA)26Sortm3(NOTCH3*R1031C)Sat/Gt(ROSA)26Sor+
Tg(Tagln-cre)1Her/0 		involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * SJL
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/07/2025
MGI 6.24 		The Jackson Laboratory