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Phenotype Image Detail
Image
Caption Severe morphological alterations in the midpiece of developing and mature sperm in Gpx4tm4Marc/Gpx4+ mice. A, transmission electron microscopy showed an increase in swollen mitochondria in late spermatids (testis) and epididymal spermatozoa (arrows). B, scanning electron microscopy of isolated sperm revealed severe morphological aberrations in the midpiece and the midpiece-principal piece junction of heterozygous spermatozoa (scale bar: A, 2 um, insets = 200 nm; B, 10 um, insets = 1 um).
Copyright This image is from Ingold I, J Biol Chem 2015 Jun 5;290(23):14668-78 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:225651
Associated
Alleles
Symbol Name
Gpx4tm4Marc glutathione peroxidase 4; targeted mutation 4, Marcus Conrad
Associated
Genotypes
Allelic Composition Genetic Background
Gpx4tm4Marc/Gpx4+ involves: 129S6/SvEvTac * C57BL/6J
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
MGI 6.23 		The Jackson Laboratory