Phenotype Image Detail

Image

Caption

H&E staining of decidua containing embryos did not reveal morphological abnormalities between wild-type (wt) and heterozygous Gpx4^tm4Marc mutant (wt/ser) embryos. In Gpx4^tm4Marc/Gpx4^tm4Marc (ser/ser) embryos, however, intrauterine resorptions of embryonic tissue were evident. Moreover, a clear distinction of the embryonic part in the three germinal layers was not unequivocally possible in contrast to heterozygous and wild-type embryos. Am, amnion; CH, chorion; EC, ectoderm; EM, embryonic tissue; EN, endoderm; EX, extraembryonic tissue; ME, mesoderm. Scale bars: white, 100 um; black, 50 um).

Copyright

This image is from Ingold I, J Biol Chem 2015 Jun 5;290(23):14668-78 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:225651

Associated Alleles

Symbol	Name
Gpx4^tm4Marc	glutathione peroxidase 4; targeted mutation 4, Marcus Conrad

Associated Genotypes

Allelic Composition	Genetic Background
Gpx4^tm4Marc/Gpx4^tm4Marc	involves: 129S6/SvEvTac * C57BL/6J