Phenotype Image Detail

Image

Caption

Runx2^tm1Hkiy/Runx2^tm1Hkiy mice show decreased bone density. (A) Mineralization of E18.5 fetuses of wild-type (+/+), Runx2^tm1Hkiy/Runx2⁺ (neo/+) and Runx2^tm1Hkiy/Runx2^tm1Hkiy (neo/neo) mice was assessed by microcomputed tomography of the whole body (upper panels) and the skull (lower panels). Scale bars: 5 mm. (B) Quantitative bone mineral parameters were calculated from femur measurements. All the parameters of homozygous mutant mice showed significantly severe deficiency of bone formation. Interestingly, heterozygous mice did not exhibit any abnormalities compared with wild-type littermates. Data are means +/- SEM (n = 4-9/group); *p<0.05, **p<0.01.

Copyright

This image is from Okura H, PLoS One 2014;9(9):e108294, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:223410

Associated Alleles

Symbol	Name
Runx2^tm1Hkiy	runt related transcription factor 2; targeted mutation 1, Hiroshi Kiyono

Associated Genotypes

Allelic Composition	Genetic Background
Runx2^tm1Hkiy/Runx2^tm1Hkiy	involves: 129P2/OlaHsd * C57BL/6
Runx2^tm1Hkiy/Runx2^+	involves: 129P2/OlaHsd * C57BL/6