Phenotype Image Detail

Image

Caption

Chondronecrosis in the articular cartilage of n-TUtca2^tm1Dhat/n-TUtca2^tm1Dhat Tg(Col2a1-cre)1Bhr/0 mice. (A) Triple-stained section of the femoral articular cartilage of a control mouse; the red staining reveals the presence of glycosaminoglycans in the extracellular matrix surrounding the embedded chondrocytes. (B) Triple-stain of femoral articular cartilage from a representative mutant mouse, showing marked glycosaminoglycan depletion (pale red regions) in the areas of chondronecrosis (arrowheads). (C) Hematoxylin and eosin-stained section of distal femoral articular cartilage from another mutant mouse, showing a typical region of chondronecrosis (arrowheads). (D) TUNEL positive apoptotic cells (stained brown) lining an area of chondronecrosis (arrowheads) in the distal femoral articular cartilage of a mutant mouse knee. Scale bar = 110 um.

Copyright

This image is from Downey CM, PLoS Genet 2009 Aug;5(8):e1000616, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:152152

Associated Alleles

Symbol	Name
n-TUtca2^tm1Dhat	nuclear encoded tRNA selenocysteine 2 (anticodon TCA); targeted mutation 1, Dolph L Hatfield
Tg(Col2a1-cre)1Bhr	transgene insertion 1, Richard R Behringer

Associated Genotypes

Allelic Composition	Genetic Background
n-TUtca2^tm1Dhat/n-TUtca2^tm1Dhat Tg(Col2a1-cre)1Bhr/0	B6.Cg-n-TUtca2^tm1Dhat Tg(Col2a1-cre)1Bhr