Phenotype Image Detail

Image

Caption

Hypoplasia of sinoatrial node (SAN) in Tbx3^tm2Moon/Tbx3^tm1.1Moon (Tbx3^GH/N) and Tbx3^tm2.1Moon/Tbx3^tm2.1Moon (Tbx3^G/G) hypomorphs. alphaHcn4 IHC (brown). (A) Serial transverse sections show normal SAN in E12.5 wild-type embryo. (B) Small SAN in E12.5 Tbx3^GH/N hypomorph. (C) Serial sagittal sections show normal SAN in wild-type newborn. (D) Small SAN in Tbx3^G/G newborn.

Copyright

This image is from Frank DU, Proc Natl Acad Sci U S A 2011 Dec 27;():. Copyright 2011 National Academy of Sciences, U.S.A. J:179977

Associated Alleles

Symbol	Name
Tbx3^tm1.1Moon	T-box 3; targeted mutation 1.1, Anne M Moon
Tbx3^tm2.1Moon	T-box 3; targeted mutation 2.1, Anne M Moon
Tbx3^tm2Moon	T-box 3; targeted mutation 2, Anne M Moon

Associated Genotypes

Allelic Composition	Genetic Background
Tbx3^tm1.1Moon/Tbx3^tm2Moon	involves: 129 * C57BL/6 * SJL
Tbx3^tm2.1Moon/Tbx3^tm2.1Moon	involves: 129 * BALB/cJ * C57BL/6 * SJL
Tbx3^tm1.1Moon/Tbx3^tm2Moon	involves: 129 * C57BL/6