Phenotype Image Detail

Image

Caption

Tbx3^tm2Moon/Tbx3^tm1.1Moon (GH/N) mutants have multiple cardiac arrhythmias. (A) Doppler ultrasound recordings of blood flow velocity (y axis) vs. time (x axis) from E12.5 ventricles. Flow into the ventricle occurs during atrial contraction ("A"), and flow out of the ventricle during ventricular contraction ("V"). Normal 1:1 ratio of A and V is shown in Tbx3⁺/Tbx3^tm1.1Moon (+/N). The Tbx3^tm2Moon/Tbx3^tm1.1Moon (GH/N) hypomorph has abnormal 5:1 and 4:1 ratios; the white arrows indicate A not followed by V. (B) Direct ECG recordings of E13.5 embryos: electrical activity (y axis) vs. time (x axis). Wild-type (+/+) shows normal P wave (atrial depolarization) followed by QRS complex (ventricular depolarization); there is 1:1 AV conduction. In a Tbx3^tm2Moon/Tbx3^tm1.1Moon (GH/N) hypomorph, QRS occurs only after every third or fourth P wave (3:1 or 4:1 AV block).

Copyright

This image is from Frank DU, Proc Natl Acad Sci U S A 2011 Dec 27;():. Copyright 2011 National Academy of Sciences, U.S.A. J:179977

Associated Alleles

Symbol	Name
Tbx3^tm1.1Moon	T-box 3; targeted mutation 1.1, Anne M Moon
Tbx3^tm2Moon	T-box 3; targeted mutation 2, Anne M Moon

Associated Genotypes

Allelic Composition	Genetic Background
Tbx3^tm1.1Moon/Tbx3^tm2Moon	involves: 129 * C57BL/6 * SJL
Tbx3^tm1.1Moon/Tbx3^tm2Moon	involves: 129 * C57BL/6