Phenotype Image Detail

Image

Caption

Cep290^{Gt(CC0582)Wtsi}/Cep290^{Gt(CC0582)Wtsi} (Cep290^LacZ/LacZ) mice exhibit progressive retinal degeneration. (A-C) Histologic analysis of H&E-stained wild-type (Cep290^+/+) and mutant retinas at (A) 4 weeks of age, (B) 6 months of age, and (C) 1 year of age showing degeneration of photoreceptor inner & outer segments, as well as a severe reduction of the outer nuclear layer in mutant mice. GCL, ganglion cell layer; INL, inner nuclear layer; IPL, inner plexiform layer; IS, inner segment; ONL, outer nuclear layer; OPL, outer plexiform layer; ROS, retinal outer segment; RPE, retinal pigment epithelium. (Scale bar: 100 um.)

Copyright

This image is from Hynes AM, Proc Natl Acad Sci U S A 2014 Jul 8;111(27):9893-8. Copyright 2014 National Academy of Sciences, U.S.A. J:212182

Associated Alleles

Symbol	Name
Cep290^Gt(CC0582)Wtsi	centrosomal protein 290; gene trap CC0582, Wellcome Trust Sanger Institute

Associated Genotypes

Allelic Composition	Genetic Background
Cep290^Gt(CC0582)Wtsi/Cep290^Gt(CC0582)Wtsi	129P2/OlaHsd-Cep290^Gt(CC0582)Wtsi