Phenotype Image Detail

Image

Caption

(A) Yolk sac and embryo morphology of control and Bmp10^{tm1.1(Gdf2)Minh}/Bmp10^{tm1.1(Gdf2)Minh} (Bmp10^9/9) mice at different stages. (B) Heart gross morphology and histology of control and homozygous mutant animals at E17.5. Up to E16.5, mutant embryos did not exhibit any gross developmental defects. Starting around E16.5, mutants were affected by apparent hemorrhage and edema, with increased severity in older embryos. At E17.5, the gross morphology of the heart became overtly abnormal, with enlarged size and altered shape (B). A majority of mutant hearts also presented with ventricular septal defects (B).

Copyright

This image is from Chen H, Proc Natl Acad Sci U S A 2013 Jul 16;110(29):11887-92. Copyright 2013 National Academy of Sciences, U.S.A. J:222016

Associated Alleles

Symbol	Name
Bmp10^tm1.1(Gdf2)Minh	bone morphogenetic protein 10; targeted mutation 1.1, Minhong Yan

Associated Genotypes

Allelic Composition	Genetic Background
Bmp10^tm1.1(Gdf2)Minh/Bmp10^tm1.1(Gdf2)Minh	C57BL/6N-Bmp10^tm1.1(Gdf2)Minh