Phenotype Image Detail

Image

Caption

Examination of cardiomyocyte nuclear ultrastructure in Syne1^tm1Chen/Syne1^tm1Chen Syne2^tm1.1ChenSyne2^tm1.1Chen Tg(Nkx2-5-cre)9Eno/? (nesprin1^f/f;nesprin2^-/- Nkx2.5Cre) mice. (A-D) Representative images of postnatal day 1 myocyte nuclei from (A) Wild-type, (B) Syne1^tm1Chen/Syne1^tm1Chen Tg(Nkx2-5-cre)9Eno/? (nesprin1^f/f;nesprin 2^+/+ Nkx2.5Cre) (C), Syne1^tm1Chen/Syne1^tm1Chen Syne2^tm1.1ChenSyne2^tm1.1Chen (nesprin1^f/f;nesprin2^-/-) or (D), Syne1^tm1Chen/Syne1^tm1Chen Syne2^tm1.1ChenSyne2^tm1.1Chen Tg(Nkx2-5-cre)9Eno/? (nesprin1^f/f;nesprin2^-/- Nkx2.5Cre) hearts. (E-H) Representative images of 10 week old myocyte nuclei from (E) wild-type (F) nesprin1^f/f;nesprin2^+/+ Nkx2.5Cre (G) nesprin1^f/f; nesprin2^-/- or (H) nesprin1^f/f;nesprin2^-/- Nkx2.5Cre hearts. Black Bars = 1 um. Red Arrows highlight electron dense heterochromatin defects in 10 week old nesprin1^f/f;nesprin2^-/- Nkx2.5Cre hearts.

Copyright

This image is from Banerjee I, PLoS Genet 2014 Feb;10(2):e1004114, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:211007

Associated Alleles

Symbol	Name
Syne1^tm1Chen	spectrin repeat containing, nuclear envelope 1; targeted mutation 1, Ju Chen
Syne2^tm1.1Chen	spectrin repeat containing, nuclear envelope 2; targeted mutation 1.1, Ju Chen
Tg(Nkx2-5-cre)9Eno	transgene insertion 9, Eric N Olson

Associated Genotypes

Allelic Composition	Genetic Background
Syne1^tm1Chen/Syne1^tm1Chen Syne2^tm1.1Chen/Syne2^tm1.1Chen Tg(Nkx2-5-cre)9Eno/?	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * Black Swiss