Phenotype Image Detail

Image

Caption

Peripheral innervation defect is evident during embryonic development in Ntrk1^tm1.1Azmo/Ntrk1^tm1.1Azmo (TrkAC-KI) mice. (A-D) Sections of E14.5 mutant and control embryos stained with anti-Ntrk1 (TrkA) antibody recognizing both Ntrk1 (TrkA) and Ntrk1/Ntrk3 (TrkAC) proteins. Labeling of dorsal root ganglia (DRGs) and projections to the spinal cord (central projections) is similar in both mutant and control animals while epidermal innervation is greatly decreased. (E and F) There are less PGP9.5 positive fibers in the skin of TrkAC-KI comparing to control embryos. (G and H) Skin innervation by TrkB-positive fibers is not changed in TrkAC-KI embryos. Scale bar is 50 um.

Copyright

This image is from Gorokhova S, PLoS Genet 2014 Feb;10(2):e1004081, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:210892

Associated Alleles

Symbol	Name
Ntrk1^tm1.1Azmo	neurotrophic tyrosine kinase, receptor, type 1; targeted mutation 1.1, Aziz Moqrich

Associated Genotypes

Allelic Composition	Genetic Background
Ntrk1^tm1.1Azmo/Ntrk1^tm1.1Azmo	involves: 129S2/SvPas