Phenotype Image Detail

Image

Caption

Aortas of Fkbp10^{tm2a(EUCOMM)Wtsi}/Fkbp10^{tm2a(EUCOMM)Wtsi} (-/-) mice have reduced wall thickness. (A) Elastin staining of E18.5 mutant embryos shows reduced wall thickness of the ascending aorta. No major defects in elastin fibers are noted. (B) Trichrome staining for collagen in the descending aorta shows no major defects in collagen and a reduced wall thickness of the descending aorta.

Copyright

This image is from Lietman CD, Hum Mol Genet 2014 Sep 15;23(18):4822-31, an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License. J:213596

Associated Alleles

Symbol	Name
Fkbp10^tm2a(EUCOMM)Wtsi	FK506 binding protein 10; targeted mutation 2a, Wellcome Trust Sanger Institute
Fkbp10^tm2a(EUCOMM)Wtsi	FK506 binding protein 10; targeted mutation 2a, Wellcome Trust Sanger Institute

Associated Genotypes

Allelic Composition	Genetic Background
Fkbp10^tm2a(EUCOMM)Wtsi/Fkbp10^tm2a(EUCOMM)Wtsi	involves: C57BL/6J * C57BL/6N