Phenotype Image Detail

Image

Caption

Morphological transformation in Ednra^{tm7(Hand2)Hku}/Ednra⁺ (Ednra^Hand2/+ chimera) ES cell-derived chimeric mice. (A) Representative surface appearance of E18.5 Ednra^Hand2/+ chimeric mice. Ednra^Hand2/+ chimeric mice demonstrate loss of vibrissae follicles, open eyelids (arrows), and polydactyly (arrowheads). (B-E) Craniofacial bone and cartilage elements of E18.5 Ednra^tm1Hku/Ednra⁺ (Ednra^Neo/+) ES cell-derived (B) and Ednra^Hand2/+ ES cell-derived (C-E) chimeric mice. Whereas Ednra^Neo/+-chimeric mice show normal skeletal morphology (B), Ednra^Hand2/+ chimeric mice demonstrate transformation of the maxilla into dentary-like bone (C), which fuses to the premaxilla and contains an ectopic incisor at the tip (D). The condylar and angular processes of the dentary, gonial, ectotympanic, and squamosal bones were often malformed or absent (E). (F-I) Craniofacial skeletons of E15.5 WT (F and H) and Ednra^Hand2/+ chimeric (G and I) mice. Ectopic formation of Meckelian cartilage (MC)-like, rod-shaped cartilage is present often with small and deformed ala temporalis in Ednra^Hand2/+-chimeric mice. The malleus, incus, stapes, and styloid process are deformed. agp, angular process; at, ala temporalis; cdp, condylar process; crp, coronoid process; dnt, dentary; etm, ectotympanic; fmx, frontal process of maxilla; gn, gonial; hy, hyoid; in, incus; jg, jugal; ma, malleus; mx, maxilla; pmx, premaxilla; sp, styloid process; sq, squamosal; st, stapes; UI, upper incisor; *, ectopic structure.

Copyright

This image is from Sato T, Proc Natl Acad Sci U S A 2008 Dec 2;105(48):18806-11. Copyright 2008 National Academy of Sciences, U.S.A. J:224515

Associated Alleles

Symbol	Name
Ednra^tm7(Hand2)Hku	endothelin receptor type A; targeted mutation 7, Hiroki Kurihara

Associated Genotypes

Allelic Composition	Genetic Background
Ednra^tm7(Hand2)Hku/Ednra^+	chimera involves: 129 * C57BL/6 * ICR