Phenotype Image Detail

Image

Caption

Histological and whole-mount neuromuscular analysis of Ednra^tm6(Edn1)Hku/Ednra⁺ (Ednra^Edn1/+) mice. (A and B) Frontal sections of E18.5 wild-type (WT) (A) and mutant (B) mice stained by Mallory trichromic. Constitutive activation of Edn1/Ednra signaling results not only in the transformation of maxillary skeletal elements, but also in the appearance of new muscular components associated to the ectopic dentary, which can be interpreted as a duplicated masseter muscle. (C and D) Cranial nerves of E10.5 WT (C) and mutant (D) embryos stained by antineurofilament antibody. Ectopic branches of the mandibular (arrow) and facial (arrowheads) nerves are indicated. dnt, dentary; mm, masseter muscle; pl, palatine; tg, tongue; gV, trigeminal ganglion; V1, ophthalmic nerve; V2, maxillary nerve; V1, mandibular nerve; VII, facial nerve; IX, glossopharyngeal nerve; *, ectopic structure.

Copyright

This image is from Sato T, Proc Natl Acad Sci U S A 2008 Dec 2;105(48):18806-11. Copyright 2008 National Academy of Sciences, U.S.A. J:224515

Associated Alleles

Symbol	Name
Ednra^tm6(Edn1)Hku	endothelin receptor type A; targeted mutation 6, Hiroki Kurihara

Associated Genotypes

Allelic Composition	Genetic Background
Ednra^tm6(Edn1)Hku/Ednra^+	involves: 129 * C57BL/6 * ICR