Phenotype Image Detail

Image

Caption

Magi2^tm1Key/Magi2^tm1Key (delta/delta) mice show early podocyte injury. (A) Representative overview of ultrastructural changes in glomeruli of wild-type (+/+) vs. mutant mice at 4 weeks of age. Whereas wild-type animals show no apparent ultrastructural changes of podocytes (marked as P), mesangial cells (marked as M) and endothelium (marked as E), mutant mice show diffuse podocyte injury, characterized by microvillous transformation and global foot process effacement. In addition, several podocytes show features of hypertrophy (asterisk), characterized by formation of long and thin cell projections, attached to glomerular capillaries (marked as C). (Scale bars: 2 um.) (B) Magnification of foot process changes. Whereas wild-type mice show intact podocyte foot processes and intervening slit diaphragms lining the glomerular basement membrane, mutant mice show diffuse foot process effacement with the characteristic basal actin condensation. (Scale bars: 1 um.)

Copyright

This image is from Balbas MD, Proc Natl Acad Sci U S A 2014;111(41):14876-81. Copyright 2014 National Academy of Sciences, U.S.A. J:213553

Associated Alleles

Symbol	Name
Magi2^tm1Key	membrane associated guanylate kinase, WW and PDZ domain containing 2; targeted mutation 1, Charles L Sawyers

Associated Genotypes

Allelic Composition	Genetic Background
Magi2^tm1Key/Magi2^tm1Key	involves: 129S4/SvJae