Phenotype Image Detail

Image

Caption

Atrioventricular valves of adult Pdlim7^{Gt(OST445990)Lex}/Pdlim7^{Gt(OST445990)Lex} (-/-) mice display abnormal morphology. Histological sections from 3-month old wild-type (+/+) and homozygous mutant hearts stained with Masson's Trichrome (A-D) and Alcian blue (E-F) exhibit normal distribution of collagens (blue, A-D) and glycosaminoglycans (blue, E-F), but elongated mitral valves in mutant mice (arrows, B, F; n=5) compared to wild-type controls (A, E; n=3). Scale bar = 100 um. Representative 3D reconstructions of serial sections of mitral (pink) and tricuspid (turquoise) valves from a wold-type (G) and mutant (H) mouse in the same anterodorsolateral perspective. Table providing quantification of increased surface area to volume ratios of atrioventricular valves in mutant (mitral, n=5; tricuspid, n=4) compared to wild-type (mitral, n=6; tricuspid, n=5) controls (I). *p<0.04. LV = left ventricle; MV = mitral valve; SA = surface area; TV = tricuspid valve; Vol = volume.

Copyright

This image is from Krcmery J, PLoS One 2013;8(11):e80809, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:209780

Associated Alleles

Symbol	Name
Pdlim7^Gt(OST445990)Lex	PDZ and LIM domain 7; gene trap OST445990, Lexicon Genetics

Associated Genotypes

Allelic Composition	Genetic Background
Pdlim7^Gt(OST445990)Lex/Pdlim7^Gt(OST445990)Lex	B6.129S5-Pdlim7^Gt(OST445990)Lex