Phenotype Image Detail

Image

Caption

Tau immunoreactivity in the brains of Tg(CMV-IghvaD11)DCat/0 Tg(CMV-IgkvaD11)ACat/0 (anti-NGF) and control mice. (a) mAbAlz50 labels hippocampal interneurones (arrows) and glial cells (asterisk) in anti-NGF mice. (c) mAb AT8 labels cortical neurones in anti-NGF mice. No labeling is observed in control mice (b and d). (e) mAb AT8 labels tangle-like structures in neurons (arrow), neuropil threads (arrowhead), and extracellular neurofibrillary deposits (asterisk) in the cortex of anti-NGF mice. (f) Treatment of cortical slices from anti-NGF mice with AP abolishes the labeling by mAbAT8. (g and h) DNA fragmentation in cortical neurones of anti-NGF (g) and control mice (h). Bar = 25 um (a, b, e, f), 75 um (c, d, g, h).

Copyright

This image is from Capsoni S, Proc Natl Acad Sci U S A 2000 Jun 6;97(12):6826-31. Copyright 2000 National Academy of Sciences, U.S.A. J:62713

Associated Alleles

Symbol	Name
Tg(CMV-IghvaD11)DCat	transgene insertion D, Antonio Cattaneo
Tg(CMV-IgkvaD11)ACat	transgene insertion A, Antonio Cattaneo

Associated Genotypes

Allelic Composition	Genetic Background
Tg(CMV-IghvaD11)DCat/0 Tg(CMV-IgkvaD11)ACat/0	involves: C57BL/6 * SJL