Phenotype Image Detail

Image

Caption

Abnormal hearts and aortic valves in Klf3^m1Cmhd/Klf3⁺ (Klf3^H275R/+) neonates. (A) Thoracic images of neonates delivered by cesarean section at E18.5 (term). The heterozygous neonate breathed occasionally for 30 min then stopped breathing and died (right). The wild type (WT) neonate (left) breathed and appeared normal before being euthanized for MRI. The ventricular myocardium (V) and septum (S) were markedly thickened in the heterozygous neonate that died. (B) Aortic valve leaflets (arrows) of a heterozygous neonate found dead on postnatal day 0 (P0) were thickened (right) relative to a same age control (left). (C) Optical Projection Tomographic images of aortic valves from apparently healthy neonates on day 1 showing thickened aortic valve leaflets in mutant (right) compared to WT (left).

Copyright

This image is from Kelsey L, PLoS Genet 2013;9(7):e1003612, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:206507

Associated Alleles

Symbol	Name
Klf3^m1Cmhd	Kruppel-like transcription factor 3 (basic); mutation 1, Centre for Modeling Human Disease

Associated Genotypes

Allelic Composition	Genetic Background
Klf3^m1Cmhd/Klf3^+	involves: C3H/HeJ * C57BL/6J