Phenotype Image Detail

Image

Caption

Impaired muscle regeneration in Wfikkn2^tm1.1Sjl/Wfikkn2^tm1.1Sjl (Gasp1^-/-), Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl (Gasp2^-/-), and Wfikkn2^tm1.1Sjl/Wfikkn2^tm1.1Sjl Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl (Gasp1^-/-;Gasp2^-/-) mice after cardiotoxin (CTX) injury. Gastrocnemius muscles at various days after CTX injury were analyzed by H&E, von Kossa (to highlight calcified fibers), and Masson trichrome (to highlight areas of fibrosis) staining. Severe myofiber degeneration, accompanied by extensive calcifications, is observed in Gasp2^-/- and Gasp1^-/-; Gasp2^-/- mice as early as 3 d after injury, and extensive areas of fibrosis are seen in Gasp1^-/-, Gasp2^-/-, and Gasp1^-/-;Gasp2^-/- mice by 14 days after injury. These abnormalities persisted at 28 days after injury. Please note that the figure is a composite of images taken from representative stained sections prepared from the individual experimental groups as indicated.

Copyright

This image is from Lee YS, Proc Natl Acad Sci U S A 2013 Sep 24;110(39):E3713-22. Copyright 2013 National Academy of Sciences, U.S.A. J:201148

Associated Alleles

Symbol	Name
Wfikkn1^tm1.1Sjl	WAP, FS, Ig, KU, and NTR-containing protein 1; targeted mutation 1.1, Sejin Lee
Wfikkn2^tm1.1Sjl	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2; targeted mutation 1.1, Sejin Lee

Associated Genotypes

Allelic Composition	Genetic Background
Wfikkn2^tm1.1Sjl/Wfikkn2^tm1.1Sjl	involves: 129 * C57BL/6
Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl Wfikkn2^tm1.1Sjl/Wfikkn2^tm1.1Sjl	involves: 129 * C57BL/6
Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl	involves: 129 * C57BL/6