Phenotype Image Detail

Image

Caption

Activation of cell cycle and death markers. Paraffin-embedded sections from aged wild-type (WT) (A, D, and H), Prnp^tm3Lnq/Prnp^tm3Lnq (CJD) (B, E, and I), and Prnp^tm2Lnq/Prnp^tm2Lnq (FFI) (C, F, and J) mice, stained with antibodies against apoptosis-inducing factor (AIF; A-C) and PCNA (D-J). Photographs were taken of the thalamus (A-F) and superior colliculus (H-J). Arrowheads in B and C mark protein staining that is not present in WT brains (A). Arrowheads in E, F, I, and J mark large, immunopositive neuronal nuclei. Immunopositive nuclei in D and H are smaller. (Scale bars: A-C, 0.03 mm; D-J, 0.05 mm.)

Copyright

This image is from Jackson WS, Proc Natl Acad Sci U S A 2013 Sep 3;110(36):14759-64. Copyright 2013 National Academy of Sciences, U.S.A. J:200974

Associated Alleles

Symbol	Name
Prnp^tm2Lnq	prion protein; targeted mutation 2, Susan Lindquist
Prnp^tm3Lnq	prion protein; targeted mutation 3, Susan Lindquist

Associated Genotypes

Allelic Composition	Genetic Background
Prnp^tm2Lnq/Prnp^tm2Lnq	involves: 129P2/OlaHsd * C57BL/6N
Prnp^tm3Lnq/Prnp^tm3Lnq	involves: 129P2/OlaHsd * C57BL/6N