Gene Expression Image Detail

Reference

Figure

ID

J:125229 Welsh IC, et al., Mech Dev. 2007 Sep-Oct;124(9-10):746-61

6

MGI:5641859

Image

Caption

(A) Whole mount in situ hybridization of the oral surface of the palatal shelves in wildtype embryos from E11.5 through E14.5. Developing rugae (numbered 1-7) and a posterior domain (pd) corresponding to the presumptive soft palate. Using expression in the molar tooth bud (asterisks) and the first distinct stripe of Shh (1) as landmarks illustrates that the relative position of these two domains remains constant whereas the number of rugae increases anterior to this position. Because new rugae are formed just anterior to stripe #1, numbering the rugae in order of their formation places each subsequently formed rugae (#3-7) between the anterior most stripe #2 and the posterior stripe #1. This results in the apparent posterior regression of the rugae forming region and presumptive soft palate relative to the rostral extension of the anterior palate (compare relative A-P positions of red asterisks). B-E: Whole mount in situ hybridization at E14.5.

Copyright

Reprinted with permission from Elsevier from 10.1016/j.mod.2007.06.007 Mech Dev 124: 746-61, Welsh IC; Hagge-Greenberg A; O'brien TP, A dosage-dependent role for Spry2 in growth and patterning during palate development. Copyright 2007

Associated
Assays

Label	Assay & Result Details (Gene Symbol)	Spatial Mapping
A E11.5	MGI:5642048 (Shh)
A E14.5	MGI:5642048 (Shh)
B	MGI:5642048 (Shh)
C	MGI:5642048 (Shh)
D	MGI:5642049 (Ptch1)
E	MGI:5642049 (Ptch1)