Phenotype Image Detail

Image

Caption

Histological analysis of wild-type (WT) and Atat1^{tm1(KOMP)Vlcg}/Atat1^{tm1(KOMP)Vlcg} (Atat1^-/-) hippocampi. A-C and E, representative hippocampal images taken from serial sections on four different sagittal planes in the medial-to-lateral direction. Nissl staining was performed; the two sections of which correspond to a sagittal position between those in A and B are shown here. Red arrowheads in A and B mark the bulge in the lateral or suprapyramidal blade of the mutant dentate gyrus. Note that at the sagittal plane no bulge was found. D and F, high resolution images of the boxed areas in C and E, respectively. Green arrows denote darkly stained cell populations within the subgranular zone of the mutant dentate gyrus. D, the peak width of the granular cell layer is shown; the width was measured with the ruler tool of the Spectrum software used to analyze images digitized by the ScanScope. Abbreviations used are as follows: CA1 and CA3, cornu ammonis areas 1 and 3 of the hippocampus, respectively; DG, dentate gyrus; gcl, granular cell layer of the dentate gyrus; pyl, pyramidal layer of CA1 or CA3; SB, subiculum. Scale bar, 500 um.

Copyright

This image is from Kim GW, J Biol Chem 2013 Jul 12;288(28):20334-50 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:201922

Associated Alleles

Symbol	Name
Atat1^tm1(KOMP)Vlcg	alpha tubulin acetyltransferase 1; targeted mutation 1, Velocigene
Atat1^tm1(KOMP)Vlcg	alpha tubulin acetyltransferase 1; targeted mutation 1, Velocigene

Associated Genotypes

Allelic Composition	Genetic Background
Atat1^tm1(KOMP)Vlcg/Atat1^tm1(KOMP)Vlcg	involves: C57BL/6 * C57BL/6NTac