Phenotype Image Detail

Image

Caption

Nlrp3^tm3.1Hhf/Nlrp3⁺ (NOMID) mice exhibit disorganized growth plates. Femoral sections from P13 (A-C) or P8 (D and E) mice were used for safranin O (A) and H&E (B, D and E) staining or for TUNEL (C). Original magnification: X20 (A and C), X10 (B, D and E). The spike (arrowhead) and early morphological changes (D, arrowhead) were observed only in NOMID mice. Mutant cells showed a high degree of apoptosis. hz, hypertrophic zone.

Copyright

This image is from Bonar SL, PLoS One 2012;7(4):e35979, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:202147

Associated Alleles

Symbol	Name
Nlrp3^tm3.1Hhf	NLR family, pyrin domain containing 3; targeted mutation 3.1, Hal M Hoffman

Associated Genotypes

Allelic Composition	Genetic Background
Nlrp3^tm3.1Hhf/Nlrp3^+	involves: 129