Phenotype Image Detail

Image

Caption

Growth retardation, micrognathia and cleft palate in Nabp2^tm1.2Kkha/Nabp2^tm1.2Kkha (Ssb1^-/-) embryos. (B) Comparison of crown-rump length of E14.5 and E18.5 wild-type (Ssb1^+/+), heterozygous (Ssb1^+/-) and homozygous mutant (Ssb1^-/-) embryos (n = minimum 3 embryos for E14.5; minimum 6 embryos for E18.5 per genotype) (*P,0.05, **P, 0.01 ***P, 0.001, student's t-test). (C) Representative sagittal sections through the heads of wild-type (i-iii) and homozygous mutant (iv-vi) P0 embryos show a misshapen snout and recessed mandible in mutant embryos. (D) Ventral skull view of E18.5 skeletal preparations with removed mandible showing clefting of the secondary palate in a mutant embryo. Scalebar = 1 mm. (E) Magnified view of (D). Note the properly fused palatine processes (arrowhead) in heterozygous control embryo (left) and lack of palatine process formation in the homozygous embryo (right), exposing the underlying presphenoid bone (arrowhead). Scale bar = 1 mm. (F) Ventral view of P0 heterozygous and homozygous heads with removed mandible showing variably penetrant cleft palate between mutant littermates. Scale bar = 1 mm.

Copyright

This image is from Shi W, PLoS Genet 2013 Feb;9(2):e1003298, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195140

Associated Alleles

Symbol	Name
Nabp2^tm1.2Kkha	nucleic acid binding protein 2; targeted mutation 1.2, Kum Kum Khanna

Associated Genotypes

Allelic Composition	Genetic Background
Nabp2^tm1.2Kkha/Nabp2^tm1.2Kkha	involves: BALB/cJ * C57BL/6J