Phenotype Image Detail

Image

Caption

Enhanced cardiomyocyte proliferation in Tg(Myh6-Yap1*S112A)#Eno/0 (Tg) mice. (A) PH3-stained sections of hearts from wild-type (WT) and transgenic (Tg) mice at P7. The green signal and white arrows indicate PH3-positive staining, and the red signal shows cTnT immunostaining. (Scale bar: 100 um). (B) PH3-stained sections of hearts from WT and Tg mice at P28. The green signal and white arrows indicate PH3-positive staining, and the red signal shows cTnT immunostaining. (Scale bar: 100 um.) (C) Quantification of PH3 immunostaining of WT and Tg neonate and adult mouse heart sections. Data are mean +/- SD. *P <0.05. (D) Wheat germ agglutinin (WGA)-stained sections of the LV compact zone in hearts of WT and Tg mice at P28 showing similar cardiomyocyte size in the two genotypes. (Scale bar: 100 um.) (E) Quantification of cardiomyocyte area. n = 3. Data are mean +/- SD. (F) Lectin Bandeiraea simplicifolia-stained sections of hearts from WT and Tg mice at P28. (G) Quantification of capillary numbers by immunostaining with lectin. n = 4. ns, not statistically significant.

Copyright

This image is from Xin M, Proc Natl Acad Sci U S A 2013 Aug 20;110(34):13839-44. Copyright 2013 National Academy of Sciences, U.S.A. J:200670

Associated Alleles

Symbol	Name
Tg(Myh6-Yap1*S112A)#Eno	transgene insertion, Eric N Olson

Associated Genotypes

Allelic Composition	Genetic Background
Tg(Myh6-Yap1*S112A)#Eno/0	involves: C3H * C57BL/6