Phenotype Image Detail

Image

Caption

SEM analysis of 2 week old cochlear sensory epithelium from Myo7a mutant strains. Apical, middle and basal cochlear turns were examined in wild-type (Myo7a+/+) (A, B and C), Myo7a^ewaso/Myo7a^ewaso (Myo7a^I487N/I487N) (D, E and F) and Myo7a^dmbo2/Myo7a^dmbo2 (Myo7a^F947I/F947I) (G, H and I) mice at 2 weeks. Misorientation of stereocilia bundles can be seen in both strains, particularly at the basal level in Myo7a^ewaso/Myo7a^ewaso mice (asterisk in F) and at all levels in Myo7a^dmbo2/Myo7a^dmbo2 mutants. Fusion of stereocilia of IHC is also evident in Myo7a^ewaso/Myo7a^ewaso at this age (arrowhead in F), and show abnormal structure in Myo7a^dmbo2/Myo7a^dmbo2 (asterisk in G). OHC, outer hair cells; IHC, inner hair cells. Scale bar; 5 uM.

Copyright

This image is from Miller KA, PLoS One 2012;7(12):e51284, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195666

Associated Alleles

Symbol	Name
Myo7a^dmbo2	myosin VIIA; dumbo2
Myo7a^ewaso	myosin VIIA; ewaso

Associated Genotypes

Allelic Composition	Genetic Background
Myo7a^ewaso/Myo7a^ewaso	involves: C57BL/6J
Myo7a^dmbo2/Myo7a^dmbo2	involves: C57BL/6J