Phenotype Image Detail

Image

Caption

Spinal cord and dorsal root ganglion (DRG). (A, B) Transverse sections of the lumbar spinal cord of wild-type (WT) and Nmnat2^{Tn(sb-Tyr)2172.P9KK4BOve}/Nmnat2^{Tn(sb-Tyr)2172.P9KK4BOve} (BLAD) mice at E18.5. Lumbar motoneurons in the spinal cord, sensory neurons in the DRG and the size of DRG are markedly reduced in BLAD mice at E18.5. (C, D) Peripheral nerves (N) from E18.5 WT (C) and BLAD (D) embryos in a lumbar region. The lightly stained regions contain axons and the dark cells in the nerve (arrows) are presumptive Schwann cells. (E) Values (Mean +/- SD) for neuron numbers for WT and heterozygous (HET) mice did not differ and have been combined for comparison with homozygous mice. DRG, dorsal root ganglion; n, nerve; dotted line encloses motoneurons in the ventral horn.

Copyright

This image is from Hicks AN, PLoS One 2012;7(10):e47869, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:192196

Associated Alleles

Symbol	Name
Nmnat2^Tn(sb-Tyr)2172.P9KK4BOve	nicotinamide nucleotide adenylyltransferase 2; targeted mutation 2172.P9KK4B, Paul A Overbeek

Associated Genotypes

Allelic Composition	Genetic Background
Nmnat2^Tn(sb-Tyr)2172.P9KK4BOve/Nmnat2^Tn(sb-Tyr)2172.P9KK4BOve	involves: FVB/N