Phenotype Image Detail

Image

Caption

Increased grade of oligodendroglioma in Gt(ROSA)26Sor^{tm1(RICTOR)Jger}/Gt(ROSA)26Sor^{tm1(RICTOR)Jger} Tg(GFAP-EGFR*,-lacZ)#Agu/0 Tg(GFAP-cre)25Mes/0 mice. H&E sections of a typical tumor displayed increased regions of necrosis and cells with pyknotic nuclei. Increased endothelial proliferation was also observed consistent with anaplastic oligodendroglioma in humans (grade 3 WHO).

Copyright

This image is from Bashir T, PLoS One 2012;7(10):e47741, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:192206

Associated Alleles

Symbol	Name
Gt(ROSA)26Sor^tm1(RICTOR)Jger	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Joseph Gera
Tg(GFAP-cre)25Mes	transgene insertion 25, Albee Messing
Tg(GFAP-EGFR*,-lacZ)#Agu	transgene insertion, Abhijit Guha

Associated Genotypes

Allelic Composition	Genetic Background
Gt(ROSA)26Sor^tm1(RICTOR)Jger/Gt(ROSA)26Sor^tm1(RICTOR)Jger Tg(GFAP-cre)25Mes/0 Tg(GFAP-EGFR*,-lacZ)#Agu/0	involves: 129S1/Sv * 129X1/SvJ * FVB/N