Phenotype Image Detail

Image

Caption

Ocular anatomy following eyelid fusion but prior to birth. H&E-stained paraffin sections of Bouin's-fixed specimens obtained at E18.5. (A) Eyelids are fused in wild-type embryos (+/+) prior to birth. (B) Eyelids are not fused in Limk2^{Gt(OST80053)Lex}/Limk2^{Gt(OST80053)Lex} (-/-) embryos. With the exception of the open eyelids, the ocular histology is comparable to wild-type. (C) Higher magnification view of a wild-type eyelid opposition shows fusion of the eyelid epithelium (ep) with the initial stages of keratinization (arrowheads) in the superficial epithelium. The basal layer of epithelium is not involved in fusion (arrows). (D) The epithelium (ep) is apparent above the basal layer (arrow) of the epidermis. However, the cornea (c) is exposed prior to birth in the mutant mice. Keratinization (arrowhead) is observed on the palpebral epidermis. Scale bar in A and B = 500 um and 100 um in C and D.

Copyright

This image is from Rice DS, PLoS One 2012;7(10):e47168, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:192231

Associated Alleles

Symbol	Name
Limk2^Gt(OST80053)Lex	LIM domain kinase 2; gene trap OST80053, Lexicon Genetics

Associated Genotypes

Allelic Composition	Genetic Background
Limk2^Gt(OST80053)Lex/Limk2^Gt(OST80053)Lex	involves: 129S5/SvEvBrd * C57BL/6