Phenotype Image Detail

Image

Caption

Ocular anatomy of newborn mice. (A) Normal appearance of newborn, postnatal day (PD) 1.5 mice. Eyelids are fused and completely cover the ocular surface at this age in wild-type mice (+/+). (B) Limk2^{Gt(OST80053)Lex}/Limk2^{Gt(OST80053)Lex} (-/-) mice exhibit an eyelid open at birth (EOB) phenotype. Upper and lower eyelids are separated and the ocular surface (arrow) is exposed. Hematoxylin and Eosin (H&E) stained paraffin sections of formalin-fixed specimens obtained at PD 1.5. (C) Wild-type mice exhibit a zone of fusion between the upper and lower eyelids (arrow) that involves only the epithelium and not the basal layer of the epidermis. (D) The upper and lower eyelids are not fused in mutant mice. Numerous cellular infiltrates can be observed in this section. Scale bar in D = 100 um.

Copyright

This image is from Rice DS, PLoS One 2012;7(10):e47168, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:192231

Associated Alleles

Symbol	Name
Limk2^Gt(OST80053)Lex	LIM domain kinase 2; gene trap OST80053, Lexicon Genetics

Associated Genotypes

Allelic Composition	Genetic Background
Limk2^Gt(OST80053)Lex/Limk2^Gt(OST80053)Lex	involves: 129S5/SvEvBrd * C57BL/6