Phenotype Image Detail

Image

Caption

Osteogenic disorder of Rgn^tm1Aish/Y mice. Rgn^tm1Aish/Y (SMP30Y^-) and wild-type ( SMP30Y⁺) mice at an age of 40 days were fed a vitamin C-deficient diet for 59 days (animals' age was 99 days). (A-D) X-ray images show the skeletal structures of wild-type (A) and mutant (B) mice. Insets show enlargements of the femoral region; an arrow points to the distal femur fracture of a mutant mouse. A rachitic rosary of the mutant mouse observed after evisceration (D) is compared with that area in a control mouse (C). Arrowheads in B and D indicate a rachitic rosary at the junction of costae and costal cartilage.

Copyright

This image is from Kondo Y, Proc Natl Acad Sci U S A 2006 Apr 11;103(15):5723-8. Copyright 2006 National Academy of Sciences, U.S.A. J:108295

Associated Alleles

Symbol	Name
Rgn^tm1Aish	regucalcin; targeted mutation 1, Akihito Ishigami

Associated Genotypes

Allelic Composition	Genetic Background
Rgn^tm1Aish/Y	involves: 129P2/OlaHsd