Phenotype Image Detail

Image

Caption

Spontaneous liver tumors developed in Mir122^tm1.1Apts/Mir122^tm1.1Apts mice. (A) A small, round-shaped, solid tumor from an 11-month-old male mutant mouse and multiple larger tumors from 3 14-month-old male mutant mice. Scale bars: 3 mm (front), 2 mm (H&E, original magnification, x0.5), 100 um (H&E, x10; and anti-PCNA) and 50 um (insets). The dotted lines show the edges of the normal liver area (N) and tumor area (T). The tumors display invasive edges.

Copyright

This image is from Tsai WC, J Clin Invest 2012 Aug 1;122(8):2884-97 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:190066

Associated Alleles

Symbol	Name
Mir122^tm1.1Apts	microRNA 122; targeted mutation 1.1, Ann-Ping Tsou

Associated Genotypes

Allelic Composition	Genetic Background
Mir122^tm1.1Apts/Mir122^tm1.1Apts	involves: 129 * C57BL/6