Phenotype Image Detail

Image

Caption

Morphological and vascular abnormalities in male hemizygous Atp7a^tm1.1Mjp/Y Cldn6^tm1(cre)Dkwu/Cldn6⁺ (Atp7a^fl/Y; Clnd6Cre^+/-) embryos. A) Developmental anomalies particularly in the frontonasal region and tail bud orientation were apparent in the mutant male embryos at E10.5. B) The blood-filled vascular network observed in wild-type embryos (Atp7a^=/Y;Cldn6Cre^+/-) and yolk sacs (arrowheads) was lacking for the mutant.

Copyright

This image is from Wang Y, PLoS One 2012;7(8):e43039, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:189931

Associated Alleles

Symbol	Name
Atp7a^tm1.1Mjp	ATPase, Cu++ transporting, alpha polypeptide; targeted mutation 1.1, Michael J Petris
Cldn6^tm1(cre)Dkwu	claudin 6; targeted mutation 1, Doris Wu

Associated Genotypes

Allelic Composition	Genetic Background
Atp7a^tm1.1Mjp/Y Cldn6^tm1(cre)Dkwu/Cldn6^+	involves: C57BL/6