Phenotype Image Detail

Image

Caption

Normal spongiosis, dendrite loss, and astrogliosis in the brains of Rocky Mountain Laboratory (RML) scrapie-infected Atp7a^Mo-3Btlr/Y (Atp7a^brown) mutants. Brain sections from uninfected wild-type males (Atp7a⁺/Y), RML scrapie-infected wild-type males (Atp7a⁺/Y), and RML scrapie-infected Atp7a^Mo-3Btlr/Y (Atp7a^brown/Y) mice killed when clinically ill were stained with H&E, antibodies against the dendrite marker MAP2, and antibodies against the astroglial marker GFAP. Arrows indicate areas of MAP2 staining and highlight dendrite loss in the RML scrapie-infected sections. Similar results to those shown were obtained for all other samples in each group (n = 3).

Copyright

This image is from Siggs OM, Proc Natl Acad Sci U S A 2012 Aug 21;109(34):13733-8. Copyright 2012 National Academy of Sciences, U.S.A. J:188598

Associated Alleles

Symbol	Name
Atp7a^Mo-3Btlr	ATPase, Cu++ transporting, alpha polypeptide; mottled 3 Bruce Beutler

Associated Genotypes

Allelic Composition	Genetic Background
Atp7a^Mo-3Btlr/Y	C57BL/6J-Atp7a^Mo-3Btlr