Phenotype Image Detail

Image

Caption

Transmission electron microscopy of sections through the hair follicle of Tgm3^tm1Sjo/Tgm3^tm1Sjo (A, C) and wild-type hair (B, D) (scale bar 10 um). Arrows show the keratin filaments. The cuticle layer is distorted in the mutant (magnified region), and disruption of the Huxley's layer is evident. Trichohyalin droplets (*) are seen as non-membrane-bound inclusions, in Huxley's layer of the inner root sheath (IRS) in both mutant (E) and control mice (F) and cornification occurs on the Henle's layer (arrow heads) (scale bar 2 um). ORS-outer root sheath, Cp-companion layer, He-Henle's layer, Hu-Huxley's layer, CI-cuticle of inner root sheath, Ch-hair cuticle, Co-hair cortex, Me-hair medulla.

Copyright

This image is from John S, PLoS One 2012;7(4):e34252, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:187109

Associated Alleles

Symbol	Name
Tgm3^tm1Sjo	transglutaminase 3, E polypeptide; targeted mutation 1, Susan John

Associated Genotypes

Allelic Composition	Genetic Background
Tgm3^tm1Sjo/Tgm3^tm1Sjo	involves: 129P2/OlaHsd * C57BL/6