Phenotype Image Detail

Image

Caption

Analysis of nuclear shape in wild-type (Lmna^+/+), Lmna^tm4Lgf/Lmna⁺ (Lmna^ggHG/+), and Lmna^tm1Lgf/Lmna⁺ (Lmna^HG/+) mouse embryonic fibroblasts (MEFs). A: Immunostaining of Lmna^tm4Lgf/Lmna⁺ and Lmna^tm1Lgf/Lmna⁺ MEFs with a lamin A-specific antibody (red). Nuclei were counterstained with DAPI (blue). Blebs are indicated with white arrows.

Copyright

This image is from Davies BS, J Lipid Res 2009 Jan;50(1):126-34 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text is from JLR. J:146099

Associated Alleles

Symbol	Name
Lmna^tm1Lgf	lamin A; targeted mutation 1, Loren G Fong
Lmna^tm4Lgf	lamin A; targeted mutation 4, Loren G Fong

Associated Genotypes

Allelic Composition	Genetic Background
Lmna^tm1Lgf/Lmna^+	involves: 129P2/OlaHsd * C57BL/6
Lmna^tm4Lgf/Lmna^+	involves: 129P2/OlaHsd * C57BL/6