Phenotype Image Detail

Image

Caption

Accumulation of DNA damage in Atmin^tm1.1Axbe/Atmin^tm1.1Axbe embryos. A, H&E staining of sagittal sections through E12.5 wild-type (ATMIN^+/+) and Atmin^tm1.1Axbe/Atmin^tm1.1Axbe (ATMIN^delta/delta) embryonic brains and high magnification of the indicated region. Top panel shows craniofacial defects and midbrain exencephaly. Lower panel shows pS139-gammaH2aX staining of a representative region and the histogram shows quantification of cells with pS139-gammaH2aX foci staining indicating presence of persistent DNA damage, n = 3.

Copyright

This image is from Kanu N, J Biol Chem 2010 Dec 3;285(49):38534-42 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:167331

Associated Alleles

Symbol	Name
Atmin^tm1.1Axbe	ATM interactor; targeted mutation 1.1, Axel Behrens

Associated Genotypes

Allelic Composition	Genetic Background
Atmin^tm1.1Axbe/Atmin^tm1.1Axbe	involves: BALB/c * C57BL/6