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Phenotype Image Detail
Image
Caption Phenotypic analysis of Sirt6tm2.2Cxd/Sirt6tm2.2Cxd mice. C-D. H&E skin sections of mutant (C) and wild-type control (D) mice at P20. Arrow in (D) points to subcutaneous fat. E. X-ray image of wild-type (upper) and mutant (lower) mice at P28. Mutant mice have reduced bone density compared with control mice (arrows).
Copyright This image is from Xiao C, J Biol Chem 2010 Nov 19;285(47):36776-84 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:167023
Associated
Alleles
Symbol Name
Sirt6tm2.2Cxd sirtuin 6; targeted mutation 2.2, Chu-Xia Deng
Associated
Genotypes
Allelic Composition Genetic Background
Sirt6tm2.2Cxd/Sirt6tm2.2Cxd involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory