Phenotype Image Detail

Image

Caption

A, a representative picture of a Timp4^tm1Vuo/Timp4^tm1Vuo (Timp4-/-) ruptured heart following myocardial infarction (MI) and trichrome-stained fixed left ventricular tissue sections showing the rupture area (arrow) and left anterior descending coronary artery ligation (arrowhead). The infarct area is marked with a dotted line. B-F, second harmonic generation (green pseudocolor) and multiphoton fluorescence (red pseudocolor) images indicating compromised fibrillar collagen and altered cellularity in Timp4^tm1Vuo/Timp4^tm1Vuo hearts post-MI. B, the depth profile extending below the heart surface. C-F, 10-um-thick maximum intensity projections of the surface and collagen layers of wild-type and mutant heart infarct regions. Scale bar, 20 um (B-F).

Copyright

This image is from Koskivirta I, J Biol Chem 2010 Aug 6;285(32):24487-93 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:165901

Associated Alleles

Symbol	Name
Timp4^tm1Vuo	tissue inhibitor of metalloproteinase 4; targeted mutation 1, Eero Vuorio

Associated Genotypes

Allelic Composition	Genetic Background
Timp4^tm1Vuo/Timp4^tm1Vuo	involves: 129S7/SvEvBrd * C57BL/6