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Phenotype Image Detail
Image
Caption A, Wild-type (WT) and Ptk2tm1.1Itl/Ptk2tm1.1Itl (R454) mouse embryo fibroblasts (MEFs) were plated onto fibronectin-coated glass slides for 1 hour and co-stained for paxillin and actin. WT MEFs formed defined leading and trailing edge cell protrusions, whereas mutant MEFs formed protrusions randomly around the cell periphery (arrows). Increased numbers of paxillin-stained FAs formed in mutant MEFs. Bar, 10 um.
Copyright This image is from Lim ST, J Biol Chem 2010 Jul 9;285(28):21526-36 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:165360
Associated
Alleles
Symbol Name
Ptk2tm1.1Itl PTK2 protein tyrosine kinase 2; targeted mutation 1.1, inGenious Targeting Laboratory
Associated
Genotypes
Allelic Composition Genetic Background
Ptk2tm1.1Itl/Ptk2tm1.1Itl involves: 129S/SvEv * C57BL/6 * SJL
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
MGI 6.23 		The Jackson Laboratory