Phenotype Image Detail

Image

Caption

Panels A-C show the proximal tibia in a female wild-type mouse. Note the thickness of the diaphyseal and metaphyseal cortical bone (C) and the thin layer of trabecular bone (Tb) at the growth plate (A). B, a higher magnification shows the normal thickness of cortical bone at the metaphysis, whereas C shows the extensive trabecular bone (pink) that normally makes up the spongiosa at the metaphysis. Panels D-F show corresponding areas of bone in an age-matched affected Akr1a1^{Gt(OST222400)Lex}/Akr1a1^{Gt(OST222400)Lex} female mouse. D, there is a complete fracture (Fx) of the bone near the metaphysis with extensive callus formation. E shows severe reduction in cortical bone thickness and periosteal fibrosis (*). F shows the complete loss of trabecular bone at the epiphysis.

Copyright

This image is from Gabbay KH, J Biol Chem 2010 Jun 18;285(25):19510-20 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:164548

Associated Alleles

Symbol	Name
Akr1a1^Gt(OST222400)Lex	aldo-keto reductase family 1, member A1; gene trap OST222400, Lexicon Genetics

Associated Genotypes

Allelic Composition	Genetic Background
Akr1a1^Gt(OST222400)Lex/Akr1a1^Gt(OST222400)Lex	B6.129S5-Akr1a1^Gt(OST222400)Lex