Phenotype Image Detail

Image

Caption

Phenotypical analysis of wild-type (+/+), Plec^tm7.1Gwi/Plec⁺ (Ogna/+) and Plec^tm7.1Gwi/Plec^tm7.1Gwi (Ogna/Ogna) mouse skin. (A) Toluidine blue dye penetration assays. Note localized breaches (arrowheads) of the skin barrier in 1-day-old Plec^tm7.1Gwi/Plec⁺ and Plec^tm7.1Gwi/Plec^tm7.1Gwi mice, not noticeable in wild-type littermates. (B) Epidermal detachment after tape stripping. Epidermal exfoliation was visible after 6 consecutive tape strippings of 1-day-old heterozygous mice using D-Square disks (CuDerm corporation, Dallas, TX) (arrow), whereas for homozygous mice, 2-3 tape strippings were usually enough for epidermal detachment (arrow). Brackets mark areas to which tape stripping was applied.

Copyright

This image is from Walko G, PLoS Genet 2011 Dec;7(12):e1002396, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:179812

Associated Alleles

Symbol	Name
Plec^tm7.1Gwi	plectin; targeted mutation 7.1, Gerhard Wiche

Associated Genotypes

Allelic Composition	Genetic Background
Plec^tm7.1Gwi/Plec^tm7.1Gwi	involves: 129P2/OlaHsd * C57BL/6
Plec^tm7.1Gwi/Plec^+	involves: 129P2/OlaHsd * C57BL/6