Phenotype Image Detail

Image

Caption

Lzts2^tm1.1Zsu/Lzts2^tm1.1Zsu mice exhibit abnormal Wolffian duct and ectopic ureteric bud formation. A, staining for Ret (c-Ret) in wild-type (+/+) and Lzts2^tm1.1Zsu/Lzts2^tm1.1Zsu (-/-) E10.5 and 11.5 embryos. The arrow indicates a normal budding uretic bud (UB) in E10.5 embryos (A1). Staining for Ret in a mutant embryo at E10.5 shows a much broader outgrowing UB (yellow arrowhead) and a bifurcated posterior end of the Wolffian duct (red arrow, A2). Staining for Ret shows that the single normal UB had extended into the metanephric mesenchyme (MM) and acquired a distinctive shape in a wild-type E11.0 embryo (red arrow, A3). Staining for Ret in a mutant embryo at E11.5 shows both ectopic UBs (yellow arrowhead) more anterior to the normal bud (red arrow). B, staining for Wnt11 in wild-type and mutant E10.5 and 11.5 embryos. The ectopic ureteric buds are marked with arrows. C, staining for Gdnf in wild-type and mutant E10.5 and 11.5 embryos. At 11.5, the wold-type embryo shows the mesenchyme (single arrow) invaded by single normal UB, but the mutant embryo appears a split mesenchyme (designated by double arrows). D, staining for Pax2 in wild-type and mutant embryos. The ectopic ureteric buds are marked with arrows.

Copyright

This image is from Peng Y, J Biol Chem 2011 Nov 18;286(46):40331-42 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:178154

Associated Alleles

Symbol	Name
Lzts2^tm1.1Zsu	leucine zipper, putative tumor suppressor 2; targeted mutation 1.1, Zijie Sun

Associated Genotypes

Allelic Composition	Genetic Background
Lzts2^tm1.1Zsu/Lzts2^tm1.1Zsu	B6.Cg-Lzts2^tm1.1Zsu
Lzts2^tm1.1Zsu/Lzts2^+	B6.Cg-Lzts2^tm1.1Zsu