Phenotype Image Detail

Image

Caption

Electron microscopy of choroidal (upper and lower left micrographs) and retinal pigment epithelium (RPE) cells (upper and lower right micrographs), including melanosomes, from wild-type C57BL/6 mice (Pmel^+/+; upper two micrographs) and Pmel^tm1.1Sson/Pmel^tm1.1Sson mice (Pmel^-/-; lower two micrographs), respectively. A scale bar is depicted in the lower left hand corner of each micrograph. Melanosomes of both choroidal and RPE cells of the affected animal appear spherical with irregular borders, the latter more obvious in the RPE cells (lower right micrographs, indicated by white arrowheads). Further, no cigar-shaped melanosomes were found in either choroidal or RPE cells in the Pmel^tm1.1Sson/Pmel^tm1.1Sson mice.

Copyright

This image is from Hellstrom AR, PLoS Genet 2011 Sep;7(9):e1002285, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:177116

Associated Alleles

Symbol	Name
Pmel^tm1.1Sson	premelanosome protein; targeted mutation 1.1, Leif Andersson

Associated Genotypes

Allelic Composition	Genetic Background
Pmel^tm1.1Sson/Pmel^tm1.1Sson	involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6