Phenotype Image Detail

Image

Caption

(A) Apoptotic cells are found in the granule cell layer (GCL) but not the Purkinje cell layer (PCL) or molecular layer (ML) of the bella/bella (bel/bel) cerebellum from P19 as indicated by TUNEL staining. (B) Cleaved caspase-3 immunostaining of bella/bella cerebellum at P24 showing positive neurons in the GCL (arrow). Sections are counterstained with cresyl violet (Nissl) indicating condensed nuclei, also indicative of apoptotic cells (arrowhead). (C) Temporal quantification of apoptotic cells in the homozygous and heterozygous cerebellum. Mean total number of TUNEL and caspase-3 positive cells from multiple parasagittal sections of the whole cerebellum show a large increase in apoptosis at P24. Scale bars: 150 uM (A), 50 uM (B).

Copyright

This image is from Oliver PL, PLoS Genet 2011 Sep;7(10):e1002338, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:177995

Associated Alleles

Symbol	Name
bella	bella

Associated Genotypes

Allelic Composition	Genetic Background
bella/bella	involves: BALB/c * C3H/HeH