Phenotype Image Detail

Image

Caption

Phenotypic analysis of Mapk14^{tm3.1(Mapk11)Nbr}/Mapk14^{tm3.1(Mapk11)Nbr} (KI/KI) mutant embryos and placenta at E11.5. (A) Severe growth retardation in Mapk14^{tm3.1(Mapk11)Nbr}/Mapk14^{tm3.1(Mapk11)Nbr} embryos compared with Mapk14^{tm3.1(Mapk11)Nbr}/Mapk14⁺ (KI/+) littermate embryos. (B-E) Hematoxylin and eosin staining of placental sections. (B and C) Abnormal layering in homozygous mutant placentas compared with heterozygous mutant placentas. (D and E) Magnification showing the reduced size of the labyrinthine layer and the thickening of the labyrinthine trophoblast in homozygous mutant placentas. Abbreviations: lt, labyrinthine trophoblast; lb, labyrinthine layer; sp, spongiotrophoblast layers. (Scale bars: 50 um).

Copyright

This image is from del Barco Barrantes I, Proc Natl Acad Sci U S A 2011 Aug 2;108(31):12764-9. Copyright 2011 National Academy of Sciences, U.S.A. J:176023

Associated Alleles

Symbol	Name
Edil3^Tg(Sox2-cre)1Amc	EGF-like repeats and discoidin I-like domains 3; transgene insertion 1, Andrew P McMahon
Mapk14^tm3.1(Mapk11)Nbr	mitogen-activated protein kinase 14; targeted mutation 3.1, Angel R Nebreda

Associated Genotypes

Allelic Composition	Genetic Background
Mapk14^tm3.1(Mapk11)Nbr/Mapk14^tm3.1(Mapk11)Nbr	Not Specified