Phenotype Image Detail

Image

Caption

(C) Histological analysis showing that Mapk14^{tm3.1(Mapk11)Nbr}/Mapk14^tm2Nbr Edil3^{Tg(Sox2-cre)1Amc}/0 Mapk11^tm1Jsca/Mapk11^tm1Jsca (p38alphaKI/delta p38betaKO) embryos have similar cardiac defects as the Mapk14^tm2Nbr/Mapk14^tm2Nbr Edil3^{Tg(Sox2-cre)1Amc}/0 Mapk11^tm1Jsca/Mapk11^tm1Jsca double knock-out embryos.

Copyright

This image is from del Barco Barrantes I, Proc Natl Acad Sci U S A 2011 Aug 2;108(31):12764-9. Copyright 2011 National Academy of Sciences, U.S.A. J:176023

Associated Alleles

Symbol	Name
Edil3^Tg(Sox2-cre)1Amc	EGF-like repeats and discoidin I-like domains 3; transgene insertion 1, Andrew P McMahon
Mapk11^tm1Jsca	mitogen-activated protein kinase 11; targeted mutation 1, J Simon C Arthur
Mapk14^tm2Nbr	mitogen-activated protein kinase 14; targeted mutation 14, Angel R Nebreda
Mapk14^tm3.1(Mapk11)Nbr	mitogen-activated protein kinase 14; targeted mutation 3.1, Angel R Nebreda

Associated Genotypes

Allelic Composition	Genetic Background
Mapk11^tm1Jsca/Mapk11^tm1Jsca Mapk14^tm2Nbr/Mapk14^tm3.1(Mapk11)Nbr Edil3^Tg(Sox2-cre)1Amc/Edil3^+	involves: 129P2/OlaHsd * C57BL/6 * CBA